Predesigned NGS community panels for forensic and ancient DNA research

Our custom panels for ancient DNA and forensics research are of broad interest to the research community and are available for quick delivery. We extend our thanks to the authors and designers of these panels for granting permission to make them available to accelerate discovery across the research community.

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Overview

Many researchers working with specimens with highly challenging degraded and/or damaged target DNA content have relied on the high performance of myBaits® Custom kits to enhance the efficiency of their research. With dedicated protocols appropriate for high-sensitivity and degraded DNA applications and extensive scientific support, myBaits has been the go-to choice for many researchers working with forensic, ancient, museum, herbarium, environmental, cell-free, and other challenging sample types.

Daicel Arbor Biosciences is your source for myBaits Custom panels designed by researchers and available to support your ancient DNA and forensics research.

Have a suggestion to add a new panel to our list? Contact us today.

Human

FORCE (V1) – FORensic Capture Enrichment

Enrichment panel targeting a focused set of SNP markers appropriate for common forensic applications, including >5.4K markers for analyses of extended kinship, ancestry, phenotype, and more. Tillmar et al (2021) designed and demonstrated this V1 (α) panel on a set of forensic and control samples. The panel provided statistically supported 1st-5th degree relationship predictions in forensic case samples.

Reference: Tillmar, A., K. Sturk-Andreaggi, J. Daniels-Higginbotham, J.T. Thomas, C. Marshall. (2021). The FORCE Panel: An All-in-One SNP Marker Set for Confirming Investigative Genetic Genealogy Leads and for General Forensic Applications. Genes 12(12):1968

Design ID: D10020FORCE1

FORCE (V2) – FORensic Capture Enrichment

The FORensic Capture Enrichment (FORCE) panel is an all-in-one SNP panel for human identification purposes. The V2 design of the FORCE myBaits panel consists of 5,402 SNPs of no clinical relevance, selected from commonly used high-density microarray chips. The FORCE panel includes 3,928 autosomal SNPs for extended kinship analyses, which were shown to provide accurate relationship predictions between fourth-degree relatives (i.e., first cousin once removed). The FORCE panel also encompasses 136 identity informative SNPs, 41 phenotype informative SNPs (HIrisPlex-S), 237 ancestry informative SNPs, 242 X-chromosomal SNPs, and 818 Y-chromosomal SNPs.

Design ID: D10223FRCv2

Parabon/AFDIL 95K Kinship Panel

Enrichment panel targeting 94,752 human SNPs for assessment of kinship out to 4th-degree relatives, particularly for highly degraded samples. Gorden et al. (2022) demonstrated this panel on a set of World War II-era highly degraded samples and a pool of family references genotyped on the Illumina CytoSNP-850K chip. The panel is designed for use with Parabon’s Fx software for extended kinship from very low-coverage sequencing data.

Reference: Gorden, E.M., E.M. Greytak, K. Sturk-Andreaggi, J. Cady, T.P. McMahon, S. Armentrout, & C. Marshall. (2022). Extended kinship analysis of historical remains using SNP capture. Forensic Science International: Genetics, 57, 102636.

Design ID: D10019SNP95K

Animal

PaleoChip Arctic-1.0 Animal - Mitochondrial genome panel for eDNA

Enrichment panel designed for capturing animal mitochondrial DNA from environmental ancient DNA (‘sedaDNA’) samples. Approximately 180 taxa were used for bait design, primarily megafauna of extinct/extant Quaternary animals. Murchie et al (2020) designed the panel and demonstrated its effectiveness on sedaDNA samples, pooled in a 5:3 ratio (Animal:Plant; total baits/rxn = 200ng) with the separate “Plant” PaleoChip Arctic-1.0″ baitset, which is also available as a Community Panel from Daicel Arbor Biosciences.

Reference: Murchie, T.J., M. Kuch, A.T. Duggan, M.L. Ledger, K. Roche, J. Klunk, E. Karpinski, D. Hackenberger, T. Sadoway, R. MacPhee, D. Froese, H. Poinar. (2021). Optimizing extraction and targeted capture of ancient environmental DNA for reconstructing past environments using the PalaeoChip Arctic-1.0 bait-set. Quaternary Research, 99:305–328.

Design ID: D10185eANML

MegaMito - Mitochondrial genome panel for eDNA

Enrichment panel designed for full mitochondrial DNA (mtDNA) genome capture from ancient DNA samples. First published and demonstrated effective in Kirillova et al (2017). Baits designed from 75 mammalian target sequences to work even for highly degraded aDNA target molecules. Target sequences include species from Artiodactyla, Carnivora, Eulipotyphla, Lagomorpha, Perissodactyla, Pholidota, Primates, Proboscidea, Rodentia, Tubulidentata, and Xenarthra.

Reference: Kirillova, I.V., O.F. Chernova, J. van der Made, V.V. Kukarskih, B. Shapiro, J. van der Plicht, F.K. Shidlovskiy, P.D. Heintzman, T. van Kolfschoten, O.G. Zanina. (2017). Discovery of the skull of Stephanorhinus kirchbergensis (Jäger, 1839) above the Arctic Circle. Quaternary Research, 88:537–550.

Design ID: D10361MgMT

Plant

PaleoChip Arctic-1.0 Plant - Chloroplast barcoding loci panel (trnL, rbcL, matK) for eDNA

Enrichment panel designed for capturing plant chloroplast DNA from environmental ancient DNA (‘sedaDNA’) samples. >2K high-latitude plant taxa were covered by the bait design, targeting the trnL, matK, and rbcL loci that are commonly used in eDNA barcoding research. Murchie et al (2020) designed the panel and demonstrated its effectiveness on sedaDNA samples, pooled in a 3:5 ratio (Plant:Animal; total baits/rxn = 200ng) with the separate “Animal” PaleoChip Arctic-1.0″ baitset, which is also available as a Community Panel from Daicel Arbor Biosciences.

Design ID: D10184ePLNT

Microbes

To view relevant panels, many of which are demonstrated to work on degraded DNA samples, please see the Microbes and metagenomics community panels page.

Note about attribution: If you use one of these Community Panels (in full or modified form) in your research, please ensure that you properly cite the appropriate publication(s) in any resulting manuscripts. Where applicable, we have indicated the most appropriate current reference(s) that should be cited for each panel.

myBaits kits are for research use only and are not validated for diagnostic or therapeutic purposes.

Publications

The featured publications listed below correspond to our current collection of Community Panels. Daicel Arbor Biosciences thanks these authors for sharing their probe designs for the benefit of the wider research community. For more examples of published papers that utilize myBaits Custom and Expert kits, please visit our Publications page.

Genes | December 10, 2021

The FORCE Panel: An All-in-One SNP Marker Set for Confirming Investigative Genetic Genealogy Leads and for General Forensic Applications

Quaternary Research | January 1, 2021

Optimizing extraction and targeted capture of ancient environmental DNA for reconstructing past environments using the PalaeoChip Arctic-1.0 bait-set

Quaternary Research | August 1, 2017

Discovery of the skull of Stephanorhinus kirchbergensi (Jäger, 1839) above the Arctic Circle

myBaits kits are for research use only and are not validated for diagnostic or therapeutic purposes.