Overview
The genes targeted by this panel were described in two major studies by Kandoth et al (2013) and Lawrence et al (2014). The myBaits Expert Onconome panel is an excellent, cost-effective choice for exploratory focused exome sequencing in a variety of research contexts, targeting ~1.5Mb of total sequence from 290 genes identified for their roles in cancer.
myBaits kits are provided as a complete solution for targeted sequencing, including buffers, bait sets, and blockers specific to the NGS library prep of choice.
- Predesigned – Optimized performance for oncology research
- Comprehensive – Pan-cancer panel targeting 1,000s of exons from 100s of genes
- Curated – Loci chosen from major cancer field publications
- Cost-effective – Lower per-reaction price than whole genome or exome sequencing
Want data even faster? Leverage our expert myReads NGS services.
myBaits kits are for research use only and are not validated for diagnostic or therapeutic purposes.
Targeted Genes
The myBaits Onconome panel was optimized through multiple design iterations to improve coverage uniformity and filter out repetitive genomic loci. Many of the selected loci are implicated in a variety of human phenotypes beyond cancer.
If you are interested in alternative target sets, the Onconome design can be customized by adding or removing specific loci from the bait set as a myBaits Custom kit. Additionally, our team of scientific experts can help design a novel custom panel for targeting non-cancer-related genes and other human genomic DNA targets to meet a specific research need. Contact us to learn more about maximizing the efficiency of any NGS study by targeting specific markers or genes of interest.
Genes included in Onconome v2 panel
- ACO1
- ACVR1B
- ACVR2A
- ACVR2B
- ADNP
- AJUBA
- AKT1
- ALK
- ALKBH6
- ALPK2
- ANK3
- APC
- APOL2
- AR
- ARHGAP35
- ARID1A
- ARID2
- ARID5B
- ASXL1
- ASXL2
- ATM
- ATP5B
- ATR
- ATRX
- AXIN2
- AZGP1
- B2M
- B4GALT3
- BAP1
- BCLAF1
- BCOR
- BHMT2
- BRAF
- BRCA1
- BRCA2
- BRE
- CAP2
- CARD11
- CASP8
- CBFB
- CCDC120
- CCDC6
- CCND1
- CD1D
- CD70
- CD79B
- CDC27
- CDH1
- CDK12
- CDK4
- CDKN1A
- CDKN1B
- CDKN2A
- CDKN2C
- CEP76
- CHD4
- CHD8
- CHEK2
- CNBD1
- CNKSR1
- COL5A1
- COL5A3
- CREBBP
- CTCF
- CTNNB1
- CUL4B
- CUX1
- DDX3X
- DDX5
- DIAPH1
- DIS3
- DNAH12
- DNER
- DNMT3A
- EGFR
- EGR3
- EIF2S2
- EIF4A2
- ELF3
- EP300
- EPHA2
- EPHA3
- EPHB6
- ERBB2
- ERBB3
- ERBB4
- ERCC2
- EZH1
- EZH2
- EZR
- FAM166A
- FAM46C
- FAT1
- FBXW7
- FGFBP1
- FGFR2
- FGFR3
- FLG
- FLT3
- FOXA1
- FOXA2
- FRMD7
- GATA3
- GNA13
- GNB1
- GNPTAB
- GOT1
- GPS2
- GUSB
- H3F3C
- HGF
- HIST1H1C
- HIST1H1E
- HIST1H2BD
- HIST1H3B
- HIST1H4E
- HRAS
- HSP90AB1
- IDH1
- IDH2
- IL7R
- ING1
- INPPL1
- INTS12
- IPO7
- IRF4
- IRF6
- ITGB7
- ITPKB
- KDM5C
- KDM6A
- KEAP1
- KEL
- KIT
- KLHL8
- KMT2A
- KMT2B
- KMT2C
- KMT2D
- KRAS
- LCTL
- LIFR
- LRRK2
- MALAT1
- MAP2K1
- MAP2K4
- MAP3K1
- MAP4K3
- MAPK8IP1
- MBD1
- MECOM
- MED12
- MED23
- MET
- MGA
- MICALCL
- MIR142
- MORC4
- MPO
- MTOR
- MUC17
- MXRA5
- MYB
- MYCN
- MYD88
- MYOCD
- NAV3
- NBPF1
- NCOR1
- NF1
- NFE2L2
- NFE2L3
- NOTCH1
- NPM1
- NRAS
- NSD1
- NTN4
- NUP210L
- ODAM
- OMA1
- OTUD7A
- PAPD5
- PBRM1
- PCBP1
- PDAP1
- PDCD2L
- PDGFRA
- PDSS2
- PHF6
- PIK3CA
- PIK3CG
- PIK3R1
- PLCG2
- POLE
- POLQ
- POU2AF1
- POU2F2
- PPM1D
- PPP2R1A
- PPP6C
- PRDM1
- PRX
- PTEN
- PTPN11
- QKI
- RAB40A
- RAC1
- RAD21
- RASA1
- RB1
- RBM10
- RHEB
- RHOA
- RIT1
- RPL22
- RPL5
- RPS15
- RPS2
- RSBN1L
- RUNX1
- RXRA
- SACS
- SELP
- SEPT12
- SERPINB13
- SETBP1
- SETD2
- SETDB1
- SF3B1
- SGK1
- SIN3A
- SIRT4
- SLC1A3
- SLC26A3
- SLC44A3
- SLC4A5
- SMAD2
- SMAD4
- SMARCA4
- SMARCB1
- SMC1A
- SMC3
- SNX25
- SOS1
- SOX17
- SOX9
- SPEN
- SPOP
- SRSF2
- STAG2
- STK11
- STX2
- TAF1
- TBC1D12
- TBL1XR1
- TBX3
- TCEB1
- TCF7L2
- TCP11L2
- TDRD10
- TET2
- TGFBR2
- TIMM17A
- TLR4
- TNFRSF14
- TP53
- TP53BP1
- TPX2
- TRAF3
- TRIM23
- TSC1
- TSHZ2
- TSHZ3
- TTLL9
- TXNDC8
- U2AF1
- USP9X
- VEZF1
- VHL
- WASF3
- WT1
- XIRP2
- XPO1
- ZFHX3
- ZNF180
- ZNF471
- ZNF483
- ZNF620
- ZNF750
- ZRANB3
myBaits kits are for research use only and are not validated for diagnostic or therapeutic purposes.
Performance
With US$15 in per-sample sequencing, percentage of targeted positions with at least 10X, 20X, and 30X unique read depth.
95% of intended positions have at least 10X read depth with minimal sequencing cost expenditure, providing the user with extremely cost-effective and focused performance from the myBaits Onconome v2 panel.
Example visualizing NGS reads from enriched human gDNA library, aligned to the hg38 genomic reference sequence.
Positions of the four myBaits OnconomeV2 probes in this region are indicated by blue bars. Unique read coverage is highest across the baited region, and tapers off upstream and downstream of the baited region, facilitating highly efficient use of NGS.
myBaits kits are for research use only and are not validated for diagnostic or therapeutic purposes.
Resources
myBaits kits are for research use only and are not validated for diagnostic or therapeutic purposes.
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