Inhibition of human-HPV hybrid ecDNA enhancers reduces oncogene expression and tumor growth in oropharyngeal cancer

This study revealed how human-HPV hybrid ecDNA enhancers drive tumor growth in HPV-positive oropharyngeal cancer—and how they can be disrupted. Using Daicel Arbor’s HPV16 FISH probes, researchers visualized these structures and identified new therapeutic targets to suppress ecDNA-driven tumors.