Deep, sensitive sequencing of complex genome methylation signals

DNA methylation is a primary epigenetic mechanism controlling a variety of biological processes, especially transcriptional regulation of cell development and various diseases, including cancer. Whole genome bisulfite sequencing (WGBS) has become the gold standard in measuring methylation status genome-wide, as it enables methylation signatures to be discovered in a wide range of sample types. However WGBS is expensive and inefficient to deploy for many samples.

Daicel Arbor Biosciences helps scientists overcome the challenges of WGBS with solutions for targeted epigenetic sequencing that:

Enable deep sequencing of methylated genomic regions of interest in a rapid, cost-effective process
Deliver customized probes for enriching bisulfite- or enzymatically-converted NGS libraries in a highly specific manner
Achieve high sensitivity and fidelity of targeted methylation detection at any level, including fully-, partially-, and non-methylated
Attain high accuracy and reproducibility against WGBS as well as between technical replicates

Want a comprehensive solution for targeted or whole-genome sequencing? Check out our customized Sequencing and Bioinformatics services.

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