Please see the kit manual for detailed technical recommendations on the enzymatic fragmentation step. In brief, the final length of your DNA after fragmentation will depend on the (1) the length of your starting genomic DNA sample and (2) your chosen fragmentation time.

myBaits hybridization capture can tolerate NGS library insert lengths from 50bp-10Kbp. However for most myBaits applications, users should aim to generate NGS libraries with ~300-500bp length inserts (~450-650bp length libraries).