myBaits Expert — Predesigned Panels
myBaits Expert Onconome
This efficient, easy-to-use kit targets thousands of exons in hundreds of human cancer-related genes.

These genes were described in two major studies: Kandoth et al 2013 “Mutational landscape and significance across 12 major cancer types” (Nature 502:333-339, doi:10.1038/nature12634) and Lawrence et al 2014 “Discovery and saturation analysis of cancer genes across 21 tumour types” (Nature 505:495-501, doi: 10.1038/nature12912). The panel targets ~1.5Mb of total sequence from 290 genes indentified between the two studies for their roles in cancer. The panel is an excellent, cost-effective choice for exploratory targeted exome sequencing in a variety of research contexts. myBaits kits are provided as a complete solution for targeted sequencing including buffers, bait sets and blockers specific to the NGS library prep of choice.

  • Predesigned – Optimized performance for oncology research
  • Comprehensive – Pan-cancer panel targeting 1000s of exons from 100s of genes
  • Curated – Loci chosen from major cancer field publications
  • Cost-effective – Lower per-reaction price than whole genome or exome sequencing
Ordering Information
Size
Cat#
Qty
Price
myBaits Onconome
Kit for enrichment of ~1.5Mb of total sequence from exons of 290 genes identified for their roles in human cancer.
304016
$1,760
Available in-stock for immediate shipment.
Overview

Comprehensive and Reliable

The myBaits Onconome panel was optimized through multiple design iterations in order to improve coverage uniformity and filter out repetitive genomic loci. Many of the selected loci are implicated in a variety of human phenotypes beyond just cancer.

If you are interested in alternative target sets, the Onconome design can be customized by adding or removing specific loci from the bait set as a the myBaits Custom kit. Additionally, our team of scientific experts can help design a fully novel custom panel for targeting non-cancer related genes, and other human genomic DNA targets to meet a specific research need. Contact us to learn more about maximizing the efficiency of any NGS study by targeting only specific markers or genes of interest.

All myBaits kits are for research-use only, and are not authorized or validated for diagnostic or therapeutic purposes.

Targeted Genes

Table 1. Genes included in Onconome v2 panel

  • ACO1
  • BRCA1
  • CUX1
  • FOXA1
  • KEL
  • MYOCD
  • PPP2R1A
  • SIRT4
  • TNFRSF14
  • ACVR1B
  • BRCA2
  • DDX3X
  • FOXA2
  • KIT
  • NAV3
  • PPP6C
  • SLC1A3
  • TP53
  • ACVR2A
  • BRE
  • DDX5
  • FRMD7
  • KLHL8
  • NBPF1
  • PRDM1
  • SLC26A3
  • TP53BP1
  • ACVR2B
  • CAP2
  • DIAPH1
  • GATA3
  • KMT2A
  • NCOR1
  • PRX
  • SLC44A3
  • TPX2
  • ADNP
  • CARD11
  • DIS3
  • GNA13
  • KMT2B
  • NF1
  • PTEN
  • SLC4A5
  • TRAF3
  • AJUBA
  • CASP8
  • DNAH12
  • GNB1
  • KMT2C
  • NFE2L2
  • PTPN11
  • SMAD2
  • TRIM23
  • AKT1
  • CBFB
  • DNER
  • GNPTAB
  • KMT2D
  • NFE2L3
  • QKI
  • SMAD4
  • TSC1
  • ALK
  • CCDC120
  • DNMT3A
  • GOT1
  • KRAS
  • NOTCH1
  • RAB40A
  • SMARCA4
  • TSHZ2
  • ALKBH6
  • CCDC6
  • EGFR
  • GPS2
  • LCTL
  • NPM1
  • RAC1
  • SMARCB1
  • TSHZ3
  • ALPK2
  • CCND1
  • EGR3
  • GUSB
  • LIFR
  • NRAS
  • RAD21
  • SMC1A
  • TTLL9
  • ANK3
  • CD1D
  • EIF2S2
  • H3F3C
  • LRRK2
  • NSD1
  • RASA1
  • SMC3
  • TXNDC8
  • APC
  • CD70
  • EIF4A2
  • HGF
  • MALAT1
  • NTN4
  • RB1
  • SNX25
  • U2AF1
  • APOL2
  • CD79B
  • ELF3
  • HIST1H1C
  • MAP2K1
  • NUP210L
  • RBM10
  • SOS1
  • USP9X
  • AR
  • CDC27
  • EP300
  • HIST1H1E
  • MAP2K4
  • ODAM
  • RHEB
  • SOX17
  • VEZF1
  • ARHGAP35
  • CDH1
  • EPHA2
  • HIST1H2BD
  • MAP3K1
  • OMA1
  • RHOA
  • SOX9
  • VHL
  • ARID1A
  • CDK12
  • EPHA3
  • HIST1H3B
  • MAP4K3
  • OTUD7A
  • RIT1
  • SPEN
  • WASF3
  • ARID2
  • CDK4
  • EPHB6
  • HIST1H4E
  • MAPK8IP1
  • PAPD5
  • RPL22
  • SPOP
  • WT1
  • ARID5B
  • CDKN1A
  • ERBB2
  • HRAS
  • MBD1
  • PBRM1
  • RPL5
  • SRSF2
  • XIRP2
  • ASXL1
  • CDKN1B
  • ERBB3
  • HSP90AB1
  • MECOM
  • PCBP1
  • RPS15
  • STAG2
  • XPO1
  • ASXL2
  • CDKN2A
  • ERBB4
  • IDH1
  • MED12
  • PDAP1
  • RPS2
  • STK11
  • ZFHX3
  • ATM
  • CDKN2C
  • ERCC2
  • IDH2
  • MED23
  • PDCD2L
  • RSBN1L
  • STX2
  • ZNF180
  • ATP5B
  • CEP76
  • EZH1
  • IL7R
  • MET
  • PDGFRA
  • RUNX1
  • TAF1
  • ZNF471
  • ATR
  • CHD4
  • EZH2
  • ING1
  • MGA
  • PDSS2
  • RXRA
  • TBC1D12
  • ZNF483
  • ATRX
  • CHD8
  • EZR
  • INPPL1
  • MICALCL
  • PHF6
  • SACS
  • TBL1XR1
  • ZNF620
  • AXIN2
  • CHEK2
  • FAM166A
  • INTS12
  • MIR142
  • PIK3CA
  • SELP
  • TBX3
  • ZNF750
  • AZGP1
  • CNBD1
  • FAM46C
  • IPO7
  • MORC4
  • PIK3CG
  • SEPT12
  • TCEB1
  • ZRANB3
  • B2M
  • CNKSR1
  • FAT1
  • IRF4
  • MPO
  • PIK3R1
  • SERPINB13
  • TCF7L2
  • B4GALT3
  • COL5A1
  • FBXW7
  • IRF6
  • MTOR
  • PLCG2
  • SETBP1
  • TCP11L2
  • BAP1
  • COL5A3
  • FGFBP1
  • ITGB7
  • MUC17
  • POLE
  • SETD2
  • TDRD10
  • BCLAF1
  • CREBBP
  • FGFR2
  • ITPKB
  • MXRA5
  • POLQ
  • SETDB1
  • TET2
  • BCOR
  • CTCF
  • FGFR3
  • KDM5C
  • MYB
  • POU2AF1
  • SF3B1
  • TGFBR2
  • BHMT2
  • CTNNB1
  • FLG
  • KDM6A
  • MYCN
  • POU2F2
  • SGK1
  • TIMM17A
  • BRAF
  • CUL4B
  • FLT3
  • KEAP1
  • MYD88
  • PPM1D
  • SIN3A
  • TLR4

Performance


Figure 1. With US$15 in per-sample sequencing, percentage of targeted positions with at least 10X, 20X, and 30X unique read depth. >95% of intended positions have at least 10X read depth with minimal sequencing cost expenditure, providing the user with extremely cost-effective and focused performance from the myBaits Onconome v2 panel.
Figure 2. Example visualizing NGS reads from enriched human gDNA library, aligned to the hg38 genomic reference sequence. Positions of the four myBaits OnconomeV2 probes in this region are indicated by blue bars. Unique read coverage is highest across the baited region, and tapers off upstream and downstream of the baited region, facilitating highly efficient use of NGS.


Save & Share Cart
Your Shopping Cart will be saved and you'll be given a link. You, or anyone with the link, can use it to retrieve your Cart at any time.
Back Save & Share Cart
Your Shopping Cart will be saved with Product pictures and information, and Cart Totals. Then send it to yourself, or a friend, with a link to retrieve it at any time.
Your cart email sent successfully :)