3D Visualization and Analysis of Genome Organization

Coupling fluorescence in situ hybridization (FISH) with 3D microscopy and image reconstruction to study spatial organization of the nuclear genome, chromatin topology and interactions between chromosomes/chromatins, which play important roles in transcriptional and epigenetic regulation of the genome function.

Super-resolution Imaging of Nuclear Organizations and Structures

Oligo-FISH in combination with super-resolution imaging techniques allows for analyzing the subcellular localization and spatial arrangement of targeted DNA sequences and RNA transcripts at the single cell level.

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