Construction and testing of gene circuits, metabolic pathways, biosensors, and artificial cells

Advances in genomics, DNA synthesis, and synthetic biology have enabled unprecedented control and creativity to design new processes and tools for the bioeconomy. Gene circuits and biosensors allow precise control over a specific response to input signals such as environmental toxins. Newly designed metabolic pathways with engineered enzymes enable optimal, sustainable production of chemicals, drugs, fuels, and food ingredients. Artificial cells that recreate early protocells can be used to explore synthetic communication networks.

Daicel Arbor Biosciences supports these synthetic biology applications with myTXTL® cell-free protein expression products that eliminate the need for preserving a living organism or performing testing in vivo and allow:

An open reaction environment that allows an immediate response to additives such as signals to turn genes on or off.
Rapid analysis without the need for growth, lysis and further processing of live cells.
Use of linear or plasmid DNA as well as RNA for multiple template formats used in biosensors, gene circuits, and artificial cells.
Creation of artificial cells by adding liposomes and expressing membrane proteins such as porins.
Easy application in automated, high- throughput workflows for increased data generation and faster discovery.