Cytogenomics
myTags – In-Situ Hybridization Probes
myTags® are oligonucleotide probes for detection and visualization of complementary genomic targets in FISH and other applications.

myTags – In-Situ Hybridization Probes

Each myTags probe pool contains unique short oligonucleotide sequences used as molecular probes to detect the presence of genomic targets and locate their spatial and temporal position in cytogenetics research, such as RNA-FISH. The short length of myTags molecular probes (43-47nt) allows for quick and efficient penetration of cell barriers and a consistent melting temperature range enables using a single hybridization profile for multiplexed fluorescent in situ hybridization (FISH) assays.

  • High Specificity – Proprietary algorithms for design and custom synthesis eliminates repetitive regions and boosts signal
  • Labeling Flexibility – Probes provided as unlabeled immortal libraries or ready-to-use labeled probes
  • Custom Probe Design – Experienced in-house design team provides scientific support and bioinformatics to customize your (F)ISH project to meet your needs

Daicel Arbor Biosciences offers both custom and catalog options in both labeled and immortal formats:

myTags Custom – Immortal and Labeled ISH Probes
Light up your cytogenomics research with flexible myTags® Custom probes for any in-situ hybridization application.
myTags Expert SARS-CoV-2
FISH probe set for localization of full-length RNA sequence of the 2019 novel coronavirus (SARS-CoV-2) responsible for COVID-19 disease.


Overview

myTags are custom-designed using assembled sequences to address many of the drawbacks associated with Bacterial Artificial Chromosome (BAC) probes. The proprietary bioinformatics design process at Daicel Arbor Biosciences uses custom genomic coordinates from assembled sequences for identification of hundreds to thousands of highly-specific molecular probe sequences for hybridization only to the intended targets.

Unlike BAC probes, myTags synthetic probes collectively provide bright and reliable signal while minimizing or eliminating background signal associated with repetitive sequences and non-specific binding. Daicel Arbor Biosciences’s proprietary oligo synthesis technology provides parallel synthesis of tens of thousands of different probe sequences in a single pool, which dramatically reduces per-oligo synthesis cost and enables consistent batch manufacturing of any scale. Then the myTags Labeling Services can be applied to convert the synthetic oligos into fluorescently-labeled probes for immediate use.

Every myTags Custom order includes expert probe design assistance for a wide variety of cytogenomics applications. myTags ISH probes are available in both labeled, ready-to-use fluorescent formats, or as immortal probe pools that are ready to be amplified and labeled on demand following the myTags labeling protocol. Labeled probes are available in a wide range of popular tagging options, including fluorophores (see Product Sheet) and haptens, perfect for multiplexed (F)ISH.

myTags ISH probes have been successfully used across a diverse range of cytogenetic applications including 3D DNA-FISH, Cryo-FISH, RNA-FISH, Oligopaints, and chromosome painting for a variety of cell types. Contact our experts today to get started on your next myTags ISH project.

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